Scientist I/II - Toxicology

Company: Takeda Pharmaceutical
Location: Brookline
Posted on: May 13, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist I/II, Toxicology, in our Cambridge, Massachusetts office. -At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. -Here, you will be a vital contributor to our inspiring, bold mission.OBJECTIVE

• Help us make safer drugs - The next generation of life changing medicines include gene therapies, oligonucleotides, and cell therapies all honed to treat previously untreatable diseases. Help us shape this next generation of life-saving medicines by improving the therapeutics selected for further development based on proactive detection & de-risking of dose limiting toxicities.
• Deliver decision-making data - Conduct state of the art in vitro assays to detect & de-risk cardiovascular and hepatic toxicities for medicines in discovery & development. Help shape the evolution of cell & gene therapies to deliver safer & more effective medicines for patients.
• Develop and validate novel in vitro models - Provide hands on support for developing and validating novel in vitro models/assays and biomarkers for safety assessment.ACCOUNTABILITIES
  • Design and perform fit-for-purpose in vitro assays to test on/off-target mechanisms of toxicities for drug candidates in discovery and development stages, with a focus on cardiac and hepatic toxicities.
  • Independently design, validate and execute novel high throughput cell-based approaches to support compound safety and research. Use molecular & cellular biology, high content imaging, and NGS technologies to generate impactful data for project teams to assess safety of drug candidates. Work closely with project teams and deliver high quality data for decision-making. -
  • Analyze, interpret and present research findings clearly and effectively at internal and external meetings.
  • Responsible for participating and interacting on matrix project teams and collaborating with investigative toxicologists to make safer medicines.EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS
    • Growing group needs scientists with Ph.D. in molecular biology, cell biology, pharmacology, toxicology or a related discipline with 0-3 years of postdoctoral experience, or MS with 4+ years' pharmaceutical industry working experience.
    • This is a wet lab R&D position, which requires hands-on technical expertise. Experience with best practices in mammalian cell culture is required, i.e. cell lines, primary cells, and iPSC-derived cells. Previous experience with liver and/or cardiovascular system is highly desirable. -
    • Cell and molecular biology skills including development of reporter assays, application of knock-out, knock-down technologies, gene expression analysis, and biomarker assay development and validation. Experience with NGS, bioinformatics tools and high content imaging is a plus.
    • Skilled in the analysis, interpretation, presentation and documentation of results.
    • Experience working in a matrixed team environment at a pharmaceutical company and/or CRO is required.
    • Broad scientific knowledge including pharmacology, toxicology, pathology, physiology and biochemistry.
    • Strong interpersonal and communication skills with an enthusiastic mindset for working in a highly collaborative and impactful scientific environment. Excellent oral and written skills are required.Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.This job posting excludes CO applicantsWHAT TAKEDA CAN OFFER YOU:
      • 401(k) with company match and Annual Retirement Contribution Plan
      • Tuition reimbursement
      • Company match of charitable contributions
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach ProgramsEEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Brookline , Scientist I/II - Toxicology, Other , Brookline, Massachusetts