Senior Medical Director, Global Medical Affairs

Company: Intellia Therapeutics
Location: Cambridge
Posted on: March 8, 2026

Job Description:

Why Join Intellia? Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. We wantall ofour people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together. Job Summary As the Medical Affairs Senior Medical Director for the lonvoguran ziclumeran (lonvo-z or NTLA-2002) hereditary angioedema program, you will embrace the challenge to create an innovative US and global Medical Affairs approach to support the launch of lonvo-z. This individual has a history of clinical and pharmaceutical industry experience, ideally in the fields of immunology, allergy, or rare diseases, with expertise in hereditary angioedema being strongly preferred. This role has four primary focus areas: KOL Engagement Strategy - Leading the development and execution of comprehensive thought leader engagement Real-world Evidence Generation - Partnering with HEOR on real-world evidence generation to develop and execute post-marketing integrated evidence plan Internal SME & Training - Serving as the in-house subject matter expert for educational initiatives Healthcare systems Strategy – Partnering with the commercial and access team on ensuring access and accessibility in the post-marketing setting The candidate will have strong experience in product launches, including proven ability to translate and appropriately align commercial and medical goals and objectives. Primary Duties/Responsibilities KOL Engagement Strategy (20%) Develop and drive strategic engagement plan with key stakeholders identified as strategic partners, including medical societies, payers, and provider groups as well as medical experts in hereditary angioedema, especially in the United States Develop relationships and drive interactions with investigators, KOLs, research institutions, and centers of excellence to oversee and support the HAE Medical Affairs plan objectives Work closely with Patient Advocacy, Medical Engagement and Regional Scientific Directors to develop and execute medical engagement strategy Play an integral role in planning and executing national and regional medical advisory boards with the HAE community Identify, map, and prioritize thought leaders across relevant geographies to engage as a global medical director strategic team, as well as identifying relevant thought leaders based on special interest topics such as research, special populations. Real-world Evidence Generation (30%) Collaborate with other line functions (Clinical Development, HEOR) to ensure that the integrated evidence generation plan is aligned with the lonvo-z HAE program objectives Provide medical support to the design and execution of research / translational analyses, clinical trial post-hoc analyses, post-marketing studies, real-world studies, and claims analyses Work closely with Access & HEOR to support key educational, engagement and evidence generation initiatives Partner on the development of real-world evidence strategies, including registry design and observational research Design and execute the investigator-led research program Provide medical expertise to support health economic modeling and value proposition development Contribute to evidence dossiers for payers and policy makers Internal Subject Matter Expert & Training Leadership (20%) Serve as the primary in-house medical affairs subject matter expert on hereditary angioedema, CRISPR technology, and lonvo-z, including completing medical/legal/review for commercial materials, as needed (cMLR committee) Deliver training programs for medical affairs, commercial, and market access teams Responsible for the medical accuracy and fair balance of medical information in educational and other medical communication and learning materials designed for an HCP audience Contribute to scientific resources, including disease overviews, competitive landscape analyses, and clinical data summaries Provide on-demand scientific consultation to cross-functional stakeholders Develop content and present at internal and external medical education programs as needed Healthcare systems Strategy (20%) Serve as the primary in-house medical affairs subject matter expert on lonvo-z systems obligations and competencies Contribute to a cross-functional team to prepare for post-marketing accessibility of lonvo-z, including prescriber and system readiness Design and execute an evidence generation plan that enables an understanding of the impact of a one-time treatment on overall healthcare system costs and burden together with Access/HEOR Additional Responsibilities (10%) Support the Medical Affairs Lead for lonvo-z in the development of short-term and long-term strategy, as well as execution of the program medical affairs plan as a key component of the integrated brand plan Participate in the Medical Access Commercialization team for HAE, together and in close partnership with the Medical Affairs Lead and Program Brand Lead Collaborate with the Scientific Communications team supporting the review and approval of publications and resources ensuring medical accuracy and alignment of all communication materials Provide medical input into the safety profile of the product in collaboration with Clinical Development and Patient Safety colleagues Requirements Skills/Abilities Robust clinical research experience within the pharmaceutical/biotech industry Previous experience within a medical affairs team with responsibility for late-stage clinical studies across multiple regions Strong track record in KOL engagement strategy development and execution Demonstrated experience leading and executing evidence generation initiatives Proven ability to serve as SME and deliver impactful training programs Solid communication, strategic, interpersonal, and negotiating skills, with ability to proactively predict challenges and solve problems Ability to drive decision-making within multi-disciplinary, multi-regional, matrix teams Diplomacy and positive influencing abilities Knowledge of both regional and global Regulatory requirements Demonstrated ability to present complex issues to management and contribute to executive level presentations and discussions Experience leading and motivating cross-functional teams and vendors/consultants Excellent interpersonal skills with an ability to respond to multiple external and internal queries, managing and handling conflict constructively Success working in a fast paced, matrixed, growing organization, partnering with multiple internal & external stakeholders Job Education / Certifications MD/PharmD Experience At least 7-10 years experience in Medical Affairs and Clinical Development in the biotechnology/pharmaceutical industry Experience in Medical Affairs leadership for products addressing rare diseases, with strong therapeutic area knowledge in hereditary angioedema, immunology, or related fields Experience with novel modalities (gene editing, CRISPR, genetic medicines) strongly preferred Track record of successful research in therapeutic areas relevant to Intellia's development programs and pipeline Physical Requirements Ability to sit or stand for multiple hours at a computer Manual dexterity for keyboarding; may include repetitive movements Travel up to 40-50% for KOL meetings, conferences, and internal training sessions LI-Remote EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Applications are accepted on a rolling basis, and will continue to be accepted until the position is filled at which point the position will be taken down. The base salary for this position is expected to range between $295,965.00 - $361,735.00 USD per year. The salary offered is determined based on a range of factors including, but not limited to, relevant education and training, overall related experience, specialized, rare or in-demand skill sets, internal comparators and other business needs. Upon joining Intellia, your salary will be reviewed periodically and additional factors such as time in role and performance will be considered. Intellia may change the published salary range based on company and market factors. Additional compensation includes a performance-based annual cash bonus, a new hire equity grant, and eligibility to be considered for annual equity awards the value of which are determined annually at the Company’s discretion. For more information about Intellia’s benefits, please click here .

Keywords: Intellia Therapeutics, Brookline , Senior Medical Director, Global Medical Affairs, Healthcare , Cambridge, Massachusetts