Postdoctoral Fellow in Gene Therapy Delivery to the Brain

Company: Brigham Women's Hospital(BWH)
Location: Brookline
Posted on: June 15, 2022

Job Description:

We are inviting applications for a Postdoctoral Fellowship position to help lead an NIH-funded project investigating delivery of gene therapies to the brain for the treatment of neurological disorders. Our laboratory uses the technology of focused ultrasound (FUS) to temporarily disrupt the blood-brain barrier for delivery of drugs and gene therapies to the brain. This preclinical project aims to deliver an AAV-packaged micro-RNA therapy targeting the gene implicated in Huntington's disease. We envision the methods developed here will be applicable to a range of gene therapy and neurological disorder combinations.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
--- Lead studies to optimize FUS-mediated delivery of AAV vectors in a mouse model.
--- Design and carry out FUS-BBB opening experiments in mice.
--- Harvest, section, stain, and image brains for markers of treatment safety and efficacy.
--- Organize and analyze data.
--- Present findings at scientific meetings and publish results in scientific journals.

START DATE:
Available immediately.
CONTACT INFORMATION:
To apply, please send a statement of interest, along with a resume to Dr. Nick Todd at: ntodd1@bwh.harvard.edu. Subject line should read "Last Name: PostDoc Position".
BRIGHAM AND
WOMEN'S HOSPITAL
HARVARD
MEDICAL SCHOOL

Qualifications
QUALIFICATIONS:
--- PhD in Immunology, Microbiology, Virology, Bioengineering, Neuroscience or related discipline.
--- Strong publication record.
--- Previous research experience with gene therapies, AAV vectors or focused ultrasound.
--- Self-motivated and independent worker.
--- Ability to work with others in an inter-disciplinary team.
All qualified applicants will receive consideration for employment without regard to gender,
race, color, religion, sex, national origin, disability, age or protected veteran status.

EEO Statement
BWH is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Keywords: Brigham Women's Hospital(BWH), Brookline , Postdoctoral Fellow in Gene Therapy Delivery to the Brain, Healthcare , Brookline, Massachusetts