Postdoctoral Fellow in Gene Therapy Delivery to the Brain
Company: Brigham Women's Hospital(BWH)
Posted on: June 15, 2022
We are inviting applications for a Postdoctoral Fellowship
position to help lead an NIH-funded project investigating delivery
of gene therapies to the brain for the treatment of neurological
disorders. Our laboratory uses the technology of focused ultrasound
(FUS) to temporarily disrupt the blood-brain barrier for delivery
of drugs and gene therapies to the brain. This preclinical project
aims to deliver an AAV-packaged micro-RNA therapy targeting the
gene implicated in Huntington's disease. We envision the methods
developed here will be applicable to a range of gene therapy and
neurological disorder combinations.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
--- Lead studies to optimize FUS-mediated delivery of AAV vectors
in a mouse model.
--- Design and carry out FUS-BBB opening experiments in mice.
--- Harvest, section, stain, and image brains for markers of
treatment safety and efficacy.
--- Organize and analyze data.
--- Present findings at scientific meetings and publish results in
To apply, please send a statement of interest, along with a resume
to Dr. Nick Todd at: firstname.lastname@example.org. Subject line should
read "Last Name: PostDoc Position".
--- PhD in Immunology, Microbiology, Virology, Bioengineering,
Neuroscience or related discipline.
--- Strong publication record.
--- Previous research experience with gene therapies, AAV vectors
or focused ultrasound.
--- Self-motivated and independent worker.
--- Ability to work with others in an inter-disciplinary team.
All qualified applicants will receive consideration for employment
without regard to gender,
race, color, religion, sex, national origin, disability, age or
protected veteran status.
BWH is an Affirmative Action Employer. By embracing diverse skills,
perspectives and ideas, we choose to lead. All qualified applicants
will receive consideration for employment without regard to race,
color, religious creed, national origin, sex, age, gender identity,
disability, sexual orientation, military service, genetic
information, and/or other status protected under law. We will
ensure that all individuals with a disability are provided a
reasonable accommodation to participate in the job application or
interview process, to perform essential job functions, and to
receive other benefits and privileges of employment.
Keywords: Brigham Women's Hospital(BWH), Brookline , Postdoctoral Fellow in Gene Therapy Delivery to the Brain, Healthcare , Brookline, Massachusetts
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