Principal Engineer, Technical Development
Company: Dyne Therapeutics
Location: Waltham
Posted on: February 23, 2026
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Job Description:
Company Overview: Dyne Therapeutics is focused on delivering
functional improvement for people living with genetically driven
neuromuscular diseases. We are developing therapeutics that target
muscle and the central nervous system (CNS) to address the root
cause of disease. The company is advancing clinical programs for
Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1
(DM1) as well as a preclinical programs for facioscapulohumeral
muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a
mission to deliver functional improvement for individuals, families
and communities. Learn more at https://www.dyne-tx.com/ , and
follow us on X , LinkedIn and Facebook . Role Summary: The
Principal Engineer, Technical Development serves as a technical
engineering lead and driver for strategy, conception, optimization,
and implementation of innovative manufacturing technologies within
the Technical Development organization. This leader blends deep
engineering expertise with cross-functional influence to implement
innovative manufacturing systems for bioprocess and bioconjugation
at clinical and commercial scales and accelerates time to market.
The role is ideal for someone who thrives at the intersection of
innovation, operations, and process development strategy. This is a
full-time position based in Waltham, MA with no option for remote
work. Primary Responsibilities: Technical Leadership Design,
optimize and implement engineering for manufacturing processes for
new and existing products under current Good Manufacturing
Practices (cGMP) Lead engineering technology selection, process
modeling, equipment specification, and system integration and
provide guidance and oversight of outsourced activities at CDMOs.
Develop and validate process control strategies, including PAT,
automation, and real time monitoring. Serve as the subject matter
expert for engineering across manufacturing, operations, and
R&D. Strategic Impact Build and execute the long-term
engineering roadmap for manufacturing capabilities across all
relevant modalities (biologics, oligonucleotides, and
bioconjugates). Identify opportunities to transition batch
processes to innovative platforms, improving throughput and
cost-of-goods, while preserving product quality. Partner with
senior leadership to align manufacturing strategy with business
goals and regulatory expectations. Cross Functional Collaboration
Work closely with Quality, Supply Chain, and Manufacturing
Operations to ensure seamless technology transfer and scaleup.
Guide technical teams through engineering design reviews, process
risk assessments, and regulatory submissions, fostering a culture
of innovation and technical excellence. Operational Excellence
Drive continuous improvement initiatives using Lean, Six Sigma, and
advanced process analytics. Troubleshoot complex manufacturing
challenges and implement robust, sustainable solutions. Ensure
compliance with cGMP, safety standards, and global regulatory
requirements. Education, Experience, and Skills Requirements:
Bachelor’s degree in chemical or similar engineering discipline
with minimum of 7 years relevant experience; advanced degree MS or
PhD preferred Proven track record designing, implementing, and
scaling manufacturing systems Hands-on approach for operation of
and troubleshooting manufacturing skids Development and
implementation of PAT technologies Experience overseeing outsourced
activities at CDMOs Expertise in process modeling, control systems,
automation, and PAT. Experience in Biologics Downstream
Purification Process Development and/or Bioconjugation Development
preferred Familiar with the concepts of Scale-Down Model
Qualification (SDMQ), Process Characterization, and defining
Process Control Strategy (PCS) Strong understanding of current Good
Manufacturing Practices (cGMP) and regulatory frameworks (FDA, EMA,
ICH) relevant to continuous manufacturing of biologics. Attention
to detail, exceptional communication skills, and the ability to
influence all levels of the organization. MA Pay Range $147,000 -
$180,000 USD The pay range reflects the base pay range Dyne
reasonably expects to pay for this role at the time of posting.
Individual compensation depends on factors such as education,
experience, job-related knowledge, and demonstrated skills. The
statements contained herein reflect general details as necessary to
describe the principles functions for this job, the level of
knowledge and skill typically required, and the scope of
responsibility, but should not be considered an all-inclusive
listing of work requirements. Individuals may perform other duties
as assigned, including work in other functional areas to cover
absences or relief, to equalize peak work periods or otherwise
balance workload. Dyne Therapeutics is an equal opportunity
employer and will not discriminate against any employee or
applicant on the basis of age, color, disability, gender, national
origin, race, religion, sexual orientation, veteran status, or any
classification protected by federal, state, or local law.
Keywords: Dyne Therapeutics, Brookline , Principal Engineer, Technical Development, Engineering , Waltham, Massachusetts
